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Home ❯ Research projects ❯ INVESTIGO GESPA 100045ID16

Funds Source:

Government of Catalonia

Period:

15/11/2022 to 15/11/2024

Project typology:

Individual project

Project status:

ACTIVE

Funding Entity:

AGAUR

Funding:

66,216 €

Anàlisis del metaboloma exposats a contaminants neurotòxics

L’objectiu del projecte postdoctoral, finançat amb el Programa Investigo, és avaluar el possible efecte terapèutic de la NAC-amida o AD4 i de diversos pèptids mimètics de la tioredoxina (TXM) en el tractament dels síndromes neurotòxics produïts per l’exposició aguda a alts nivells de pesticides organofosforats, acrilamida i MeHg.

L’investigador desenvolupa mètodes analítics pel control d’aquests contaminants i dels seus metabòlits, utilitzant instrumentació analítica com LC-MS/MS o LC-Q-TOF. El projecte analitza l’efecte terapèutic de la NAC-amida i dels pèptids TXM en models neurotòxics en peix zebra i ratolins. També s’estudiarà els canvis en el metaboloma dels organismes model exposats als contaminants. El projecte postdoctoral està fortament alineat amb el projecte “New generation of Drugs Protecting against Neurotoxic Industrial Chemicals – NeuroTICs” (SPS-G5852), finançat per la OTAN.

Research groups

GESPA – Engineering and Simulation of Environmental Processes Group

GESPA's research is focused on the topics of environmental sustainability from a transversal perspective. GESPA is a consolidated research group by the Catalan Government (2021 SGR 00321) and consists of a multidisciplinary team of scientists who combine chemical engineering, biotechnology and advanced chemical analysis with a theoretical-experimental approach to improve the sustainability of our society.