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Home ❯ Research projects ❯ mRNA vaccines for metastatic melanoma treatment: systemic vs. local delivery

mRNA vaccines for metastatic melanoma treatment: systemic vs. local delivery

Funds Source:

Other entities

Period:

01/01/2024 to 31/12/2024

Project status:

ACTIVO

Funding:

20.000,00€

The main aim of the whole project is the comparison of the immunogenic and therapeutic potential between a local vs a systemic mRNA vaccine for the treatment of metastatic melanoma.

Specifically, in this call, we aim to design two different devices for the local delivery, a hollow microneedle and a polysaccharide hydrogel. Thus, the specific aims of the project are:
1) Design a polysaccharide hydrogel, embedded with antigenic mRNA-loaded pBAE nanoparticles.
2) Design of a PLGA hollow microneedle, loaded with antigenic mRNA-loaded pBAE nanoparticles.
3) In vitro confirmation of the safety and immunogenicity of both delivery systems.

Research groups

GEMAT – Materials Engineering

The GEMAT group (Materials Engineering Group) conducts its activity in three main areas: the development of new functional materials, surface engineering and biomaterials.