The Biotehrapies Laboratory is specialized in the development of peptides and proteins, especially antibodies, with biomedical applications.
Equipment and technologies
This laboratory conducts R+D+i and technology transfer activities by combining chemistry and synthetic biology to contribute to the generation of new biotherapies.
- Development of peptides and proteins for biomedical applications.
- Antibody engineering and chemistry to generate bispecifics, antibody-drug conjugates, and conditionally-active biologics.
- Identification of new functional peptides and proteins combining library selections and directed evolution and rational design.
- Study and engineering of transport systems to cross the blood-brain barrier.
- Development of bio- and nano- therapeutics, especially for cancer treatment.
Equipment and technologies
- Automated microwave-assisted peptide synthesizer Liberty Blue™ 2.0.
- FPLC BioRad NGC Quest 10 for protein purification
- Agilent 6230 UHPLC-UV-MS time-of-flight (TOF) liquid chromatograph for the characterization of intact proteins and other biomolecules
- Other equipment for peptide and protein development: microvolume spectrophotometer, thermocycler, thermostated incubators, laminar flow hood, chemical hoods, thermostated centrifuges and an adjoining cell culture room
- Preparative HPLC Agilent Infinity II 1260 for peptide purification
- ChemiDoc MP imaging system with UV, visible, fluorescence and chemiluminescence detection
- Octet® R2 biolayer interferometry (BLI) system for measuring biomolecule interactions
